Table 1: Studies of neighborhood disadvantage and myocardial infarction risk and survival.
Author |
Design |
Outcomes |
Sample |
Results |
Alter et al., (1999) |
Population-based study in Ontario, Canada |
Total mortality |
51,591 patients with acute myocardial infarction |
A strong inverse association was observed with neighborhood income (p<0.001). Each $10,000 increase in the neighborhood median income was associated with a 10% reduction in the risk of death within one year (hazards ratio [HR] = 0.90, 95% CI 0.86, 0.94). |
Tyden et al., (2002) |
Cohort study in Malmo, Sweden |
Total mortality |
Myocardial infarction patients |
The sex- and age-adjusted all-cause mortality rate per 1,000 patient years ranged from 85.5 to 163.6 between residential areas. The area specific relative risk (RR) of death after discharge was associated with a low socioeconomic score (r=0.56, p=0.018). |
Stjarne et al., (2004) |
Population-based case-control study in Stockholm, Sweden |
Incident myocardial infarction |
1,631 cases of myocardial infarction and matched controls |
The adjusted RR of myocardial infarction was 2.0 (95% CI 1.3, 3.1) for women living in the top quartile of materially deprived areas. For men, the adjusted RR was 1.6 (95% CI 1.2, 2.1). |
Stjarne et al., (2006) |
Population-based case-control study in Stockholm County, Sweden |
Acute myocardial infarction |
2,246 cases of myocardial infarction and matched controls |
The level of neighborhood socioeconomic resources had a contextual effect on the RR of myocardial infarction. Compared with high-income neighborhoods, the incidence rate ratio in low income neighborhoods was 1.88 (95% CI 1.25, 2.84) for women and 1.52 (95% CI 1.16, 1.99) for men. |
Chaix et al., (2007) |
Cohort study in the Scania region, Sweden |
Incident myocardial infarction and death from IHD |
52,084 persons at risk of myocardial infarction |
The incidence of myocardial infarction increased with neighborhood socioeconomic deprivation. For high vs. low neighborhood socioeconomic deprivation, the hazard ratio (HR) was 1.7 (95% CI 1.4, 2.0). A similar pattern was seen for IHD mortality. |
Beard et al., (2008) |
Population-based study in New South Wales, Australia |
Deaths from acute myocardial infarction and hospital admissions for acute coronary syndrome |
Persons at risk of acute myocardial infarction or acute coronary syndrome |
Area-level socioeconomic disadvantage (defined using Census variables relating to education, occupation, non-English speaking background, indigenous origin, and household economic resources) was related to mortality (RR for highest quartile of disadvantage relative to lowest = 1.40, 95% CI = 1.27, 1.54). |
Rose et al, (2009) |
Population-based cohort study in four U.S. communities |
Incident hospitalized myocardial infarction |
Persons at risk of incident hospitalized myocardial infarction |
Within each community, and among all race-gender groups, those living in low neighborhood median household income neighborhoods had an increased risk of myocardial infarction compared to those living in high neighborhood median household income neighborhoods. |
Davies et al., (2009) |
Population-based study in Scotland |
Incident acute myocardial infarction |
5.1 million persons at risk of acute myocardial infarction |
The socioeconomic gradient in acute myocardial infarction increased over time (p<0.001). Among males, the gradient across area deprivation categories in 1990-1992 was most pronounced at younger ages. The RR of acute myocardial infarction in the most deprived areas compared to the least was 2.6 (95% CI 1.6, 4.3) for those aged 45-59 years and 1.6 (95% CI 1.1, 2.5) at 60-74 years. A similar pattern was seen in women. |
Gerber et al. (2010) |
Cohort study of patients discharged from 8 Israeli hospitals |
Total mortality and cardiac mortality |
1,179 patients with incident myocardial infarction |
Patients residing in disadvantaged neighborhoods had higher mortality rates, with 13-year survival estimates of 61%, 74%, and 82% in increasing tertiles (p-trend < 0.001). The HRs for death associated with neighborhood socioeconomic status were 1.47 (95% CI 1.05, 2.06) in the lower tertile and 1.19 (95% CI 0.86, 1.63) in the middle tertile compared with the upper tertile (p-trend = 0.02). |
Henriksson et al., (2010) |
Population-based study in Sweden municipalities |
Acute myocardial infarction and total mortality
|
Persons at risk for acute myocardial infarction |
Risk for acute myocardial infarction was lower in the municipalities with higher degree of income inequality. |
Deguen et al., (2010) |
Population-based study in Strasbourg metropolitan area, France |
Myocardial infarction |
Persons at risk of myocardial infarction |
The risk of myocardial infarction increased with the neighborhood deprivation level. Women appeared to be more susceptible at levels of extreme deprivation. |
Blais et al., (2012) |
Population-based study in Quebec |
Total mortality |
50,242 patients with acute myocardial infarction |
Based upon a population deprivation index, the most materially and socially deprived patients had a 16% (95% CI 1.08, 1.25) and 13% (95% CI 1.05, 1.21) relative increased hazard of dying within 1 year, respectively, compared with the most privileged subjects. |
Koren et al., (2012) |
Hospital-based cohort study in Israel |
Recurrent myocardial infarction
|
1,164 patients with incident myocardial infarction |
The hazards of recurrent myocardial infarction was higher in low socioeconomic status neighborhoods (HR = 1.55, 95% CI 1.13, 2.14). |
Koopman et al., (2012) |
Population-based cohort study in The Netherlands. |
Incident acute myocardial infarction
|
Persons at risk of acute myocardial infarction |
When comparing the most deprived neighborhood-level socioeconomic quintile with the most affluent quintile, the overall RR for acute myocardial infarction was 1.34 (95% CI 1.32, 1.36) in men and 1.44 (95% CI 1.42, 1.47) in women. |
Kim et al., (2014) |
Retrospective cohort study at one referral center in South Korea |
Total mortality |
2,358 patients hospitalized for acute myocardial infarction |
No significant association was seen between a neighborhood socioeconomic status indicator (social deprivation index) and mortality. |
Thorne et al., (2015) |
Record linkage study in Wales |
30-day mortality following acute myocardial infarction |
Patients hospitalized for acute myocardial infarction |
Social deprivation was significantly associated with higher mortality for acute myocardial infarction. |
Kim et al., (2018) |
Quasi-experimental study in Toronto, Canada area |
Incident myocardial infarction and total mortality |
Residents of public housing |
Living in a public housing project in the second highest neighborhood socioeconomic position was non-significantly associated with lower hazards of acute myocardial infarction (HR = 0.76, 95% CI 0.54, 1.07, p = 0.11) and all-cause mortality (HR = 0.86, 95% CI 0.73, 1.01, p=0.06). |