Sl no.

Cancer

Role

Function

Ref

1.

Glioblastoma

Tumor

Suppressor

gene

The study delineates that the long isoform of ERR-β downregulates the Glioblastoma cell migration due to the interaction with the actin nucleation factor cortactin.

[19]

2.

Prostate cancer

Tumor

Suppressor

gene

ERRβ plays a pivotal role in downregulating the expression pattern in ERR-β transduced and non-transduced cells. The study also reveals that ERR β /γ agonist DY131 plays a potential role in ERR-β mediated growth inhibition.

[9]

3.

Uterine cancer

Yet to be known

 Studies Corroborate the functional characterization of exogenous ERRβsf and ERRβ2 in the ERα-positive Ishikawa endometrial cancer cell line. Study reveals that Exogenous ERR β2 enhances ER α activity upon estrogen induction at an ERE-luciferase reporter, while ERRβsf abrogated ERα activity. 

[20]

4.

Ovarian cancer

Oncogene

Studies reveal the high protein expression of the Orphan receptor ERRβ in the various subtypes of serous ovarian malignancies which indicates a significantly shorter overall patient survival.

[21]

5

Breast Cancer

Tumor

Suppressor

gene

Studies report the overexpression of ERRβ in patient samples compared to normal samples.

Expression of ERRβ is Erα dependent and ERRβ is a direct potential target of Erα.

There is an evident decrease in the expression of ERRB in breast cancer, which is mediated by the proteasomal pathway via Cullin1.

[22, 23]