Table 2: Summarizes the nanoparticles modified platforms
with specific oncogenes to detect HPV with their high sensitivity.
|
S.No. |
Gene
Specific for HPV |
Nanocomposite
and electrodes used |
Detection limit |
Sensitivity |
Linear Range |
Reference |
|
1. |
HPV16 |
platinum surface/polyaniline-multiwalled carbon
nanotube composite
|
490pM
|
1.75 ± 0.2 μA nM-1 |
10nM-50nM
|
[47] |
|
2. |
HPV16 |
4-aminothiophenol, on a polymethylmethacrylate
substrate with a gold nanolayer
|
NR |
NR |
NR |
[48] |
|
3. |
HPV16 and HPV18
|
graphene/Au nanorod/polythionine
|
4.03×10-14 mol/L |
NR |
1.0×10-13
|
[49] |
|
4. |
HPV16 and HPV18
|
acpcPNA probe/gold deposited SPCE
|
0.1-1000nM
|
NR |
0.5nM-100nM
|
[50] |
|
5. |
HPV 16 |
porous reduced graphene oxide/Molybdenum
disulfide |
1.75pM |
2.35-0.76 (ng mL-1) |
3.5pM-35.3pM |
[45] |
|
6. |
HPV16 |
graphene-polyaniline (G-PANI) |
2.3nM |
NR |
10nM-200nM |
[51] |
|
7. |
HPV 16 and HPV 18 |
CysSso7d/Au NP (gold nanoparticles) |
1.00ng mL-1
|
85.7%/100.0% and 85.7%/91.7% |
to 1.00×103 ng mL-1
|
[52] |
|
8. |
HPV16
|
gold nanosheets
|
0.15pM
|
NR |
1pM-1μM
|
[53] |
|
9. |
HPV16
|
titanium dioxide nanoparticles |
∼ 0.1fM |
40x 10-4 (AM-1) |
10fM-10μM |
[54] |
|
10 |
HPV16
|
AuNTs-PC |
1fM |
0.01pM |
0.01pM to 1μM |
[55] |
|
11. |
HPV18
|
Ti3C2 nanosheets |
100pM |
NR |
1.0nM and 50nM |
[56] |
|
12. |
HPV18
|
rGO and MWCNTs |
0.05fM |
NR |
0.01fM to 0.01nM |
[57] |
*NR= Not reported