Table 4: Univariate and multivariable Cox regression analysis about risk factors
of reduced disease-free survival.
|
|
Univariate analysis on DFS |
Multivariable analysis on DFS |
||||
|
Variable |
HR |
CI95% |
p |
HR |
CI95% |
p |
|
Sex female |
1.83 |
0.96-3.49 |
0.06 |
1.56 |
0.78-3.11 |
0.2 |
|
Age>70 years |
1.15 |
0.6-2.2 |
0.67 |
|
|
|
|
ADC |
1.56 |
0.76-3.2 |
0.22 |
|
|
|
|
pN0 pN1 pN2 |
ref 0.73 1.85 |
0.24-2.16 0.93-3.67 |
0.57 0.079 |
0.71 1.61 |
0.24-2.14 0.78-3.31 |
0.55 0.19 |
|
Pathological stage III |
2.03 |
1.07-3.88 |
0.03 |
1.76 |
0.89-3.47 |
0.1 |
|
LNR LNR 0 LNR <0.29 LNR >0.29 |
ref 1.2 2.4 |
0.54-2.67 1.1-5.23 |
0.65 0.027 |
1.14 2.89 |
0.51-2.56 1.23-6.77 |
0.73 0.047 |
|
ypN2 |
1.96 |
1.01-3.81 |
0.046 |
1.72 |
0.86-3.45 |
0.12 |
|
Adjuvant CHT |
1.5 |
0.78-2.91 |
0.22 |
|
|
|
|
PORT |
1.72 |
0.6-4.88 |
0.3 |
|
|
|
|
Adjuvant CHT-RT |
0.96 |
0.38-2.4 |
0.94 |
|
|
|
|
R1 |
2.32 |
1.07-5.04 |
0.032 |
1.58 |
0.5-4.98 |
0.43 |
DFS: Disease-Free Survival,
HR: Hazard Ratio; CI95%: Confidence Interval 95%; ADC: Adenocarcinoma; LNR:
Lymph Node Ratio; CHT: Chemotherapy; PORT: Post-Operative Radiation Therapy;
CHT-RT: Chemo-Radiation Therapy; R1: Microscopic Incomplete Resection.