Index Therapy

Docetaxel

Abiraterone

Cabazitaxel

Enzalutamide

Overall

n=134

n=250

n=2

n=61

N=447

Age

Mean ± SD

69.8 ±8.2

73.8 ±8.9

74 ±8.5

76.1 ±7.4

72.9 ±8.8

95% Confidence Interval (CI)

[68.4 ; 71.2 ]

[72.6 ; 74.9]

[0 ; 150.2 ]

[74.3; 78.0]

[72.1; 73.4]

Charlson Comorbidity Index

Mean (SD)

8.3 ±2.9

8.1 ±3.1

8 ±0

7.7 ± 3.1

8.1 ±3

95% Confidence Interval (CI)

[7.8 ; 8.8]

[7.7; 8.5]

[8.0; 8.0]

[ 6,9 ; 8,4 ]

[7.8; 8.4]

Location of metastasis N (%)

Total involving bone

94 (70.1%)

182 (72.8%)

2 (100.0%)

35 (57.4%)

313 (70.0%)

            Bone

34 (25.4%)

84 (33.6%)

1 (50.0%)

16 (26.2%)

135 (30.2%)

            Bone + Visceral

24 (17.9%)

49 (19.6%)

0 (0 %)

9 (14.8%)

82 (18.3%)

            Bone + Other

18 (13.4%)

24 (9.6%)

0 (0 %)

3 (4.9%)

45 (10.7%)

            Bone + Other + Visceral

18 (13.4%)

25 (10%)

1 (50.0%)

7 (11.5%)

51 (11.5%)

Visceral

7 (5.2%)

7 (2.8%)

0 (0%)

2 (3.3%)

16 (3.6%)

Other

2 (1.5%)

8 (3.2%)

0 (0%)

1 (1.6%)

11 (2.5%)

Other + Visceral

3 (2.2%)

6 (2.4%)

0 (0%)

2 (3.3%)

11 (2.5%)

None

28 (20.9%)

47 (18.8%)

0 (0%)

21 (34.4%)

96 (21.5%)

All cause hospitalizations 12 months before index

Mean ±SD

2.3 ±2.7

1.7 ±2.5

0.5 ±0.7

1.7 ±2.7

1.9 ±2.6

95% Confidence Interval

[1.8; 2.8]

[1.4; 2.0]

[0; 6.8]

[1.0; 2.4]

[1.6; 2.1]