Index treatment

Defined as first line if there was no previous chemotherapy or treatment with any of the drugs of interest in the look back period

Line of treatment

Determined by sequence of treatments following the index treatment

Line Start date

Oral: Date of first prescription

IV: Date of first administration according to OPS code for the administration of cabazitaxel or docetaxel

Line End date

The earlier of the following:

• Prescription of a new drug (=a new active substance, switch to another ATC or OPS),
• Death
• Oral: Date of last prescription plus package size (30 days)
• Intravenous (IV): Date of last cycle plus cycle length.

Treatment holiday

Spell without treatment: gap between end date line n and start date of line n+1

Re-Challenge

A new line of the same treatment if the treatment was prescribed or administered more than 6 weeks (42 days) after the end of the calculated previous treatment line.

Censoring event

End of observation time

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