DFS

OS

PR

95%CI

P

PR

95%CI

P

Lower

Upper

Lower

Upper

Whole cohort

Age

1.486

1.023

2.314

0.002

2.586

1.680

3.892

0.001

WBC

1.359

1.024

2.035

0.035

1.864

1.025

2.684

0.002

Karyotype

1.567

1.068

2.984

0.028

1.756

0.766

3.236

0.123

NPM1/FLT3-ITD

0.246

0.168

0.650

0.006

0.423

0.196

0.875

0.004

CEBPA^{double-mutation}

0.586

0.368

0.964

0.027

0.489

0.203

0.965

0.013

RUNX1

1.698

1.123

2.645

0.034

1.796

0.864

3.125

0.059

WT1

1.975

1.238

2.941

0.003

1.925

1.029

3.258

0.042

ASXL1

0.998

0.621

1.789

0.758

1.368

0.843

2.465

0.458

TET2

0.996

0.635

1.645

0.861

1.241

0.639

1.963

0.923

IDH2

0.842

0.523

1.321

0.346

0.654

0.351

0.944

0.013

MLL/PTD

1.456

0.764

2.415

0.402

1.325

0.582

3.359

0.421

DNMT3A

2.014

1.314

3.014

0.001

2.011

1.214

3.684

<0.001

TP53

2.358

1.216

5.240

0.019

4.982

2.017

12.092

0.001

Older patients

WBC

1.568

0.741

3.125

0.359

1.945

0.782

4.285

0.123

Karyotype

0.895

0.362

3.147

0.978

1.456

0.634

5.369

0.345

NPM1/FLT3-ITD

0.457

0.158

1.235

0.056

0.365

0.064

0.865

0.012

CEBPA^{double-mutation}

0.968

0.403

2.645

0.752

0.571

0.150

2.654

0.356

RUNX1

0.965

0.456

3.687

0.552

1.842

0.531

4.026

0.341

ASXL1

1.532

0.642

3.452

0.769

1.365

0.511

3.684

0.765

TET2

1.245

0.513

2.065

0.652

1.055

0.523

2.658

0.954

IDH2

0.965

0.180

1.245

0.069

0.358

0.160

1.482

0.116

MLL/PTD

1.647

0.597

4.639

0.486

2.349

0.698

9.621

0.095

DNMT3A

1.769

0.860

3.564

0.235

3.158

1.356

8.032

0.002

TP53

2.325

0.652

10.451

0.368

4.024

1.023

18.456

0.032