Table 1: Prognostic factors in patients with refractory/relapsed acute myeloid leukemia (n=45).
Parameter |
n |
Median survival time (Months) |
2 year-OS(%) |
Chi-square |
P value |
|
Age |
|
|
|
|
9.178 |
0.012 |
<60 years ≥60 years |
28 |
13±4.43 |
36.4±0.96 |
|
||
17 |
3±0.68 |
0 |
||||
Gender |
|
|
|
|
0.219 |
0.718 |
Male Female |
24 |
8.00±3.262 |
18.9±1.08 |
|
|
|
21 |
9±4.577 |
23.8±9.3 |
|
|
||
Performance status |
|
|
|
2.891 |
0.189 |
|
0-1 2-3 |
25 |
6±3.37 |
38.5±10.4 |
|
|
|
20 |
9±2.91 |
7.1±6.5 |
|
|
||
Type of AML |
|
|
|
3.375 |
0.403 |
|
Primary Secondary |
42 |
10±2.92 |
49±7.9 |
|
|
|
3 |
3±1.63 |
0 |
|
|
||
Cytogenetic abnormality |
|
|
|
0.597 |
0.478 |
|
Favorable Intermediate Poor Missing |
4 |
9±1.10 |
- |
|
|
|
11 |
10±3.60 |
- |
|
|
||
11 |
7±3.56 |
- |
|
|
||
19 |
6±8.49 |
27.8±10.6 |
|
|
||
CR duration |
|
|
|
3.241 |
0.198 |
|
<6 months |
19 |
4±1.36 |
18.9±9.4 |
|
|
|
6-12 months |
9 |
- |
- |
|
|
|
>12months |
17 |
13±3.54 |
10.8±9.6 |
|
|
|
HSCT before relapse |
|
|
|
0.225 |
0.635 |
|
Yes No |
5 |
7±2.18 |
4.34 |
|
|
|
40 |
16±8.22 |
47±8 |
|
|
||
HSCT after relapse |
|
|
|
15.236 |
<0.0001 |
|
Yes no |
15 |
- |
6.6±5.7 |
|
|
|
30 |
4±1.39 |
55.1±13.9 |
|
|