LRC

DFS

OS

Variable

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Age <50 vs 50-59

0.68 (0.23, 1.99)

0.48

0.61 (0.25, 1.49)

0.28

0.57 (0.22, 1.48)

0.25

Age <50 vs 60-69

0.60 (0.18, 2.01)

0.41

0.56 (0.23, 1.36)

0.20

0.64 (0.24, 1.69)

0.37

Age <50 vs 70

0.67 (0.22, 2.02)

0.47

1.00 (0.44, 2.28)

>0.99

1.68 (0.70, 3.99)

0.24

Clinical T Stage cT1-2 vs cT3-4

1.36 (0.64, 2.88)

0.42

1.21 (0.71, 2.07)

0.48

1.70 (0.95, 3.04)

0.072

p16 Status negative vs positive

0.25 (0.10, 0.68)

0.006

0.25 (0.13, 0.49)

<0.001

0.25 (0.12, 0.52)

<0.001

CD44 Score <163  vs 163+

2.78 (1.16, 6.65)

0.022

1.86 (1.00, 3.47)

0.050

2.15 (1.11, 4.15)

0.023

c-MET Score <187 vs  187+

2.10 (0.91, 4.84)

0.082

1.41 (0.78, 2.53)

0.26

1.91 (1.02, 3.57)

0.044

MTOR Score <86 vs 86+

1.37 (0.55, 3.44)

0.50

1.54 (0.80, 2.97)

0.20

1.25 (0.61, 2.57)

0.54

EGFR Score <32 vs 32+

2.07 (0.83, 5.14)

0.12

1.95 (1.05, 3.60)

0.034

2.19 (1.12, 4.28)

0.022

GLUT1 Score <187 vs 202+

0.51 (0.18, 1.45)

0.21

0.56 (0.26, 1.19)

0.13

0.61 (0.28, 1.30)

0.20

GLUT1 <187 vs unknown

0.78 (0.21, 2.87)

0.70

0.89 (0.35, 2.27)

0.81

1.22 (0.46, 3.22)

0.69