LRC

DFS

OS

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Age       

<50 vs 50-59

<50 vs 60-69

<50 vs 70+

1.0 (0.37-2.7)

0.48 (0.15-1.5)

1.0 (0.35-2.9)

0.995

0.199

0.981

1.1 (0.47-2.3)

0.68 (0.30-1.6)

1.8 (0.84-4.0)

0.910

0.372

0.131

0.94 (0.4-2.3)

0.64 (0.26-1.6)

2.53 (1.1-5.8)

0.893

0.331

0.027

T stage (cT1-2 vs cT3-4)

1.9 (0.95-3.9)

0.068

1.8 (1.1-3.0)

0.022

2.3  (1.4-4.0)

0.002

N stage (cN0-2a vs cN2b-cN3)

1.1 (0.55-2.3)

0.741

1.3 (0.76-2.1)

0.368

1.3 (0.74-2.2)

0.383

Primary other vs oropharynx

0.39 (0.19-0.80)

0.010

0.34 (0.21-0.56)

<0.001

0.31 (0.18-0.53)

<0.001

p16  Negative vs Positive

0.19 (0.08-0.45)

<0.001

0.22 (0.13-0.38)

<0.001

0.19 (0.10-0.36)

<0.001

CD44  <163 => 163

4.0 (2.0-8.1)

<0.001

3.0 (1.7-5.0)

<0.001

3.0 (1.7-5.3)

<0.001

c-MET <187 => 187

2.8 (1.3-5.6)

0.006

1.8 (1.1-3.0)

0.020

2.2 (1.3-3.7)

0.005

MTOR < 86 => 86

1.5 (0.7-3.2)

0.292

1.6 (0.9-2.8)

0.085

1.6 (0.9-2.9)

0.121

EGFR < 32 => 32

2.1 (0.9-4.6)

0.079

2.0 (1.2-3.6)

0.013

2.2 (1.2-4.0)

0.014

GLUT1 <187 => 187

2.29 (1.1-5.0)

0.038

2.41 (1.4-4.2)

0.002

2.82 (1.6-5.0)

<0.001

GLUT1 unknown

3.03 (1.1-8.4)

0.033

2.55 (1.2-5.6)

0.019

3.17 (1.4-74)

0.007