Table 3: Multivariable analysis of pre-surgical clinical factors associated with adverse pathologic features (Grade Group ≥3, pT≥3, pN+) in patients who had prostatectomy as initial treatment for prostate cancer.
|
|
|
Odds Ratio (95% CI) |
|
|
Variables |
LR-PC |
FIR-GG1 |
FIR-GG2 |
|
Age, years 45-55 55.1-65 65.1-75 >75 |
REF 1.36 (1.27-1.46) 1.61 (1.49-1.74) 0.82 (0.59-1.13) |
REF 1.0 (0.81-1.23) 0.95 (0.76-1.2) 0.25 (0.11-0.59) |
REF 1.3 (1.21-1.4) 1.5 (1.38-1.62) 0.73 (0.57-0.93) |
|
Race White Black |
REF 1.04 (0.95-1.12) |
REF 0.94 (0.75-1.18) |
REF 0.87 (0.8-0.95) |
|
Charlson score 0 1 2 ≥3 |
REF 1.11 (1.03-1.19) 1.19 (0.99-1.43) 1.34 (0.97-1.85) |
REF 1.22 (0.99-1.51) 1.03 (0.61-1.72) 2.05 (1.03-4.11) |
REF 1.06 (0.98-1.13) 0.97 (0.81-1.15) 1.19 (0.89-1.57) |
|
Clinical T stage cT1 cT2 |
REF 1.17 (1.06-1.28) |
REF 1.02 (0.75-1.39) |
REF 1.38 (1.28-1.5) |
|
PSA, ng/ml |
1.14 (1.12-1.15) |
1.06 (1.03-1.09) |
1.11 (1.09-1.12) |
|
Number of positive cores ≤2 3-5 ≥6 |
REF 1.67 (1.57-1.77) 2.38 (2.21-2.55) |
REF 1.63 (1.39-1.92) 2.09 (1.33-3.3) |
REF 1.27 (1.2-1.34) 1.5 (1.34-1.68) |