Table 2: Univariate and multivariate analyses.
|
|
|
Distant recurrence-free survival |
|
|
|
Cancer-related death |
|
|
|
Overall survival |
|
|
|
|
|
|
Univariate |
|
Multivariate |
|
Univariate |
|
Multivariate |
|
Univariate |
|
Multivariate |
|
|
|
N= |
HR (95% CI) |
P- value |
HR (95% CI) |
P- value |
HR (95% CI) |
P- value |
HR (95% CI) |
P- value |
HR (95% CI) |
P- value |
HR (95% CI) |
P- value |
|
Age (mean) |
174 |
0.98 (0.953 - 1.017) |
0.338 |
|
|
0.99 (0.960 - 1.029) |
0.721 |
|
|
1.04 (1.011 - 1.069) |
0.006 |
1.04 (1.015-1.070) |
0.002 |
|
Gender |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
92 |
0.65 (0.314 - 1.333) |
0.238 |
|
|
0.49 (0.224 - 1.069) |
0.073 |
|
|
1.02 (0.612 - 1.693) |
0.947 |
|
|
|
Female |
82 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Grade |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G1 and G2 |
141 |
0.49 (0.147 - 1.603) |
0.236 |
|
|
0.54 (0.163 - 1.793) |
0.314 |
|
|
0.79 (0.388 - 1.604) |
0.512 |
|
|
|
G3 and G4 |
33 |
|
|
|
|
|
|
|
|
|
|
|
|
|
T stage |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
T3 |
144 |
0.73 (0.255 - 2.096) |
0.561 |
|
|
1.10 (0.417 - 2.907) |
0.846 |
|
|
1.32 (0.716 - 2.448) |
0.37 |
|
|
|
T4 |
30 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Tumor location |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Caecum and right colon |
42 |
Reference |
|
|
|
Reference |
|
|
|
Reference |
|
|
|
|
Sigmoid and left colon |
87 |
0.60 (0.246 - 1.474) |
0.267 |
|
|
0.34 (0.136-0.827) |
0.018 |
0.32 (0.131-0.796) |
0.014 |
0.38 (0.205-0.691) |
0.002 |
0.36 (0.196-0.661) |
0.001 |
|
Flexures and transverse colon |
45 |
1.08 (0.425 - 2-730) |
0.875 |
|
|
0.62 (0.246-1.583) |
0.321 |
0.56 (0.220-1.1435) |
0.228 |
0.72 (0.382-1.371) |
0.321 |
0.78 (0.412-1.482) |
0.45 |
|
Therapy |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Surveillance |
86 |
1.06 (0.518 - 2.175) |
0.871 |
|
|
1.01 (0.476 - 2.153) |
0.976 |
|
|
0.89 (0.536 - 1.476) |
0.651 |
|
|
|
5-FU / LV |
88 |
|
|
|
|
|
|
|
|
|
|
|
|
|
TSR |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stroma-low |
138 |
2.32 (1.102 - 4.872) |
0.027 |
2.32 (1.102 - 4.872) |
0.027 |
2.30 (1.054 - 5.027) |
0.037 |
2.38 (1.082-5.220) |
0.031 |
1.25 (0.685 - 2.271) |
0.47 |
|
|
|
Stroma-high |
36 |
|
|
|
|
|
|
|
|
|
|
|
|