Features of MCREV

Measurements or related factors

Intensity

The absolute differences between the peak and the lowest estrogen levels within a menstrual cycle (See Figure 1)

Timing

Early menarche (earlier time of exposure to the hazard);

Age of first full-term pregnancy (earlier time of temporary pause of exposure to the hazard)

Frequency

Menstrual cycle length (Shorter menstrual cycle length relates more frequent exposure to the MCREV)

Duration

Early menarche and late menopause;

Number of pregnancies;

Lactation (breastfeeding)