Table 2: Comparison of frequently utilized prognostic scoring systems for brain metastases.
|
|
RPA (n=1200) |
SIR (n=65) |
Rotterdam (n=1292) |
BSBM (n=110) |
Rades (n=1797) |
GGS (n=479) |
GPA (n=1960) |
DS-GPA (n=4259) |
|
Age |
Yes |
Yes |
|
|
Yes |
Yes |
Yes |
Yes |
|
Performance status |
KPS |
KPS |
ECOG |
KPS |
KPS |
KPS |
KPS |
KPS |
|
Primary control |
Yes |
Yes |
|
Yes |
|
|
|
|
|
ECM |
Yes |
Yes |
Yes |
Yes |
Yes |
Yes |
Yes |
Yes |
|
Number of BM |
|
Yes |
|
|
Yes |
Yes |
Yes |
Yes |
|
Volume of BM |
|
Yes |
|
|
|
|
|
|
|
Steroid response |
|
|
Yes |
|
|
|
|
|
|
Tumor histology |
|
|
|
|
|
Yes |
Yes |
Yes |
|
Interval from diagnosis to RT |
|
|
|
|
Yes |
|
|
|
|
ER/PR status |
|
|
|
|
|
|
|
Yes |
|
HER-2 status |
|
|
|
|
|
|
|
Yes |
|
EGFR status |
|
|
|
|
|
|
|
Yes |
|
EML4-ALK status |
|
|
|
|
|
|
|
Yes |
|
BRAF status |
|
|
|
|
|
|
|
Yes |
|
AFP |
|
|
|
|
|
|
|
Yes |
|
Child-Pugh-Score |
|
|
|
|
|
|
|
Yes |
Note: Empty spaces represents for ‘No’.
RPA: Recursive Partitioning Analysis Scoring System; SIR: Score index for radiosurgery; BSBM: Basic score for brain metastases; GGS: Golden grading system; GPA: Graded prognostic assessment; DS-GPA: Disease specific graded prognostic assessment; ECM: Extracellular matrix; BM: Brain metastasis; RT: Radiotherapy; ER: Estrogen receptor; PR: Progesteron receptor; HER-2: Human epidermal growth factor receptor 2; EGFR: Epidermal growth factor receptor; EML4-ALK: Echinoderm microtubule associated protein-like 4 and anaplastic lymphoma kinase; BRAF: v-Raf murine sarcoma viral oncogene homolog B; AFP: Alpha fetoprotein.