Table 2: Median HE4 values (range) in different body fluids presented by group.
|
|
Control n=11 |
Benign n=10 |
Borderline n=10 |
Malignant n=22 |
Significancea |
|
Serum (pmol/L) |
42 (29-68) |
77 (38-154) |
81 (44-126) |
137 (46-3328) |
p<0.001 |
|
Urine (nmol/L) |
5.28 (0.70-18.7) |
6.79 (3.26-41.2) |
7.62# (1.94-17.0) |
20.2 (0.4-904) |
p=0.02 |
|
HE4/creatinine ratio |
0.72 (0.24-0.90) |
0.93 (0.27-1.33) |
1.03# (0.55-3.69) |
1.60 (0.11-35.1) |
p=0.02 |
|
Cervix (nmol/L) |
0.81 (0.28-9.67) |
6.99 (0.04-49.0) |
6.38# (0.14-35.7) |
5.81 (0.02-29.0) |
p=0.09 |
|
Cervical HE4/protein ratio (nmol/g) |
6.73 (0.87-44.2) |
12.0 (0.36-107) |
16.8# (0.36-261) |
5.77 (0.05-125.6) |
p=0.79 |
|
Saliva (nmol/L) |
15.2 (2.97-43.8) |
13.7 (6.37-56.5) |
27.1# (5.26-69.3) |
20.8 (6.55-78.8) |
p=0.45 |
|
Ascites (nmol/L) |
NA |
0.29 (0-1.76) |
0.91# (0.43-6.63) |
1.66 (0.02-13.4) |
p=0.04 |
a Statistical significant difference in median values between groups was calculated using Kruskal Wallis test; # missing values of two patients.