Table 3: Acute toxicities during TPF and CCRT.

 

TPF (n=28)

CCRT (n=27)

Toxicity/Grade

1

2

3

4

1

2

3

4

Vomiting

6 (21.4%)

2 (7.14%)

2 (7.14%)

0

3 (11.1%)

2 (7.41%)

3 (11.1%)

0

Diarrhea

6 (21.4%)

2 (7.14%)

7 (25%)

0

0

0

0

0

HFS

1 (3.57%)

0

0

0

0

0

1 (3.70%)

0

Neutropenia

1 (3.57%)

0

1 (3.57%)

2 (7.14%)

4 (14.8%)

5 (18.5%)

7 (25.9%)

1 (3.70%)

Neutropenic fever

1 (3.57%)

0

1 (3.57%)

0

2 (7.40%)

0

1 (3.70%)

0

Non-neutropenic infection

0

2 (7.14%)

1 (3.57%)

0

0

0

2 (7.40%)

0

Anaemia

17 (60.7%)

6 (21.4%)

2 (7.14%)

0

10 (37.0%)

8 (29.6%)

9 (33.3%)

0

Thrombocytopenia

7 (25%)

0

0

0

11 (40.7%)

5 (18.5%)

0

0

Hearing loss

0

0

0

0

1 (3.70%)

0

0

0

Mucositis

1 (3.57%)

0

0

0

2 (7.41%)

12 (44.4%)

13 (48.1%)

0

Neuropathy

2 (7.14%)

0

0

0

0

1 (3.70%)

0

0

Impaired renal function

9 (32.1%)

0

0

0

14 (51.9%)

1 (3.70%)

0

0

Increased alanine transaminase

7 (25%)

1 (3.57%)

0

0

2 (7.40%)

1 (3.70%)

0

0

Increased bilirubin

0

0

0

0

0

0

0

0

Hypokalaemia

14 (50%)

3 (10.7%)

0

0

6 (22.2%)

4 (14.8%)

0

0

Hyponatremia

13 (46.4%)

2 (7.14%)

2 (7.14%)

1 (3.57%)

13 (48.1%)

0

2 (7.41%)

0

Skin Reaction

 

 

 

 

11 (40.7%)

12 (44.4%)

3 (11.1%)

0

Tube Feeding

 

 

 

 

3 (11.1%)

0

0

0

Others*

0

0

0

1 (3.57%)*

 

 

 

 

CCRT: Concurrent Chemoradiotherapy; HFS: Hand Foot Syndrome; *ST- elevation myocardial infarction. *estimated 3-year OS; §estimated 3-year PFS.