Table 1: Demographic and clinical characteristics, laboratory measurements and haemodynamics.
|
|
Total |
Ct-FGF23 tertiles [RU/mL] |
Sig. |
||||||||
|
|
n = 149 |
≤ 15.70 |
15.71 – 37.10 |
> 37.10 |
|
||||||
|
|
Median (IQR) |
Median |
Median |
Median |
p-Value |
||||||
|
Demographic and clinical characteristics |
|
|
|
|
|||||||
|
Age [years] |
49.7 (38.5 – 61.7) |
50.2 |
49.4 |
49.7 |
0.983 |
||||||
|
BMI [kg/m2] |
24.81 (22.00 – 27.74) |
25.47 |
25.80 |
24.20 |
0.183 |
||||||
|
Sex, men [%] |
65.3 |
54.0 |
75.0 |
67.3 |
0.088 |
||||||
|
Syst. BP [mmHg] |
120 (110 – 132) |
120 |
121 |
120 |
0.291 |
||||||
|
Heart rate [bpm] |
71 (60 – 82) |
70 |
67 |
76 |
0.103 |
||||||
|
NYHA class l |
22.8 |
30.0 |
25.5 |
12.5 |
- |
||||||
|
NYHA class ll |
43.4 |
50.0 |
48.9 |
31.3 |
- |
||||||
|
NYHA class lll/lV |
33.8 |
20.0 |
25.5 |
56.3 |
0.001 |
||||||
|
Laboratory measurements |
|
|
|
|
|||||||
|
NT-proBNP [ng/L] |
1340 (501 – 3266) |
903 |
986 |
3028 |
< 0.001 |
||||||
|
eGFR [mL/min/1.73m2] |
73.78 (58.31 – 90.20) |
80.59 |
73.78 |
61.06 |
< 0.001 |
||||||
|
≤ 60 mL/min/1.73m2 [%] |
26.8 |
10.0 |
25.0 |
46.9 |
< 0.001 |
||||||
|
≤ 45 mL/min/1.73m2 [%] |
4.7 |
0.0 |
2.1 |
12.2 |
0.010 |
||||||
|
Neopterin [nmol/L] |
6.90 (5.00 – 9.70) |
5.60 |
6.50 |
8.80 |
< 0.001 |
||||||
|
hsCRP [mg/L] |
0.20 (0.10 – 0.63) |
0.16 |
0.17 |
0.35 |
0.033 |
||||||
|
Phosphate [mmol/L] |
1.10 (0.97 – 1.22) |
1.07 |
1.08 |
1.17 |
0.002 |
||||||
|
PTH [ng/L] |
37.91 (27.28 – 53.67) |
35.57 |
34.87 |
48.05 |
0.050 |
||||||
|
Vitamin D [nmol/L] |
46.4 (29.3 – 67.1) |
49.1 |
37.7 |
48.5 |
0.732 |
||||||
|
Haemodynamics |
|
|
|
|
|
|
|
||||
|
LV-EF [%] |
37.0 (25.7 – 49.7) |
40.5 |
42.0 |
31.0 |
0.254 |
||||||
|
mean PAP [mmHg] |
26 (19 – 33) |
24 |
23 |
31 |
0.011 |
||||||
|
RAP [mmHg] |
9 (6 – 12) |
9 |
8 |
11 |
0.013 |
||||||
|
PCWP [mmHg] |
17 (12 - 25) |
16 |
15 |
21 |
0.007 |
||||||
|
Cardiac index [L/min/m2] |
1.93 (1.68 – 2.42) |
2.08 |
1.98 |
1.78 |
0.013 |
||||||
Data from 149 patients are presented as median (interquartile range) in the total study population and within the Ct-FGF23 tertiles.
Sig: significance; BMI: body mass index; syst. BP: systolic blood pressure; bpm: beats per minute; NYHA: new ork heart association; NT-proBNP: N-terminal prohormone of brain natriuretic peptide; eGFR: estimated glomerular filtration rate; hsCRP: high sensitive C-reactive protein; Ct-FGF23: C-terminal fibroblast growth factor 23; PTH: parathormone; LV-EF: left ventricular ejection fraction; mean PAP: mean pulmonary artery pressure; RAP: right atrial pressure; PCWP: pulmonary capillary wedge pressure.