Target

Mutation

Frequency (%)

EGFR

Exon 19 deletion and exon 21 point mutation

HER2 point mutation

T790M (somatic)

30-60

2-4

1-4

KRAS

Mutations in codons 12, 13, and 61

15-25

ALK

EML4-ALK

2-8

NTRK1

NTRK1 fusion

3.3

c-MET

Amplification

Exon 14 skipping mutation

2-4

3-4

BRAF

V600E mutation

1-4

ROS1

ROS1

2

RET

RET fusion

1

Co-mutations

Upto 15