Table 3: Treatment toxicity and hospital admission following TPF chemotherapy.
Treatment toxicity, incidence and duration, reported following the first cycle of TPF. Admissions to hospital by length of stay and including the commonest causes for admission.
|
toxicity |
|
number evaluable |
number with toxicity (%) |
|
neutropenia * |
neutrophils ≤1.5 neutrophils ≤1.0 |
99 |
21 20 |
|
diarrhoea * |
none at any time lasting 1-3 days lasting 4-7 days lasting 8-10 days lasting 11-14 days |
103
58 |
23 80 (78) 31 20 5 2 |
|
mucositis * |
none at any time lasting 1-3 days lasting 4-7 days lasting 8-10 days lasting 11-14 days |
100
23 |
52 48 (48) 6 12 3 2 |
|
in-patient admission (first cycle) |
patients admitted admitted 1-3 days admitted 4-7 days admitted 8-14 days admitted ≥15 days neutropenic sepsis infection (non-neutropenic) diarrhoea † |
108 |
42 (39) 11 16 7 6 17 8 8 |
|
in-patient admission (second cycle) |
patients admitted admitted 1-3 days admitted 4-7 days admitted 8-14 days admitted ≥15 days neutropenic sepsis infection (non-neutropenic) diarrhoea ‡ |
103 |
21 (20) 8 5 5 3 1 7 3 |
*: toxicity following the first cycle only.
†: includes two patients with diarrhoea due to Campylobacter and one with Clostridium difficile.
‡: includes one patient with diarrhoea due to Clostridium difficile.