Grades

Clinical domain

Functional domain

1

Dysesthesia/paresthesia, tingling in hands and feet.

Inconvenience without disturbing daily activities.

2

Difficulty in walking and holding objects, painless swelling and erythema.

Difficulty in doing daily activities.

3

Swelling in palms and soles with painful erythema,

periungual erythema and swelling.

Severe discomfort, inability to work or perform diurnal activities.

4

Desquamation, ulceration, blistering, severe pain.

Severe discomfort, inability to work or perform diurnal activities.