Table 1B: Case reports available in literature.
|
Author |
Preoperative diagnosis |
Treatment |
Tumor biology |
Follow-up |
||||||||||||||||||||
|
Author (year) |
Year |
Age |
Clin pres |
US |
MX |
CT |
PET |
Bio / Cit |
Nadj treat |
Surgery |
Adj treat |
Adj RT |
pTNM |
Tum size |
LNs |
Histo-type |
CrA |
Syn |
ER |
PR |
Her2 |
Ki67 |
FUP (mo) |
Alive status |
|
Wade[23] |
1983 |
52 |
UBM N+ |
MBM |
MBM |
Neg |
NO |
Bio |
NO |
Mast + ALND |
VP-16 |
NO |
T4N1M0 |
10 |
25/25 |
SCNC |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
|
Jundt[24] |
1984 |
52 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
TXN1M1 |
NA |
+/? |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
14 |
DOD |
|
Francois[25] |
1995 |
68 |
BM |
HeBM |
HBM |
Neg |
NO |
Cit |
NO |
Mast + ALND |
CPA/ADR/VP-16 |
Yes |
T2N0M0 |
4 |
0/12 |
SCNC |
NA |
NA |
- |
NA |
NA |
NA |
21 |
DUC |
|
Chua[26] |
1997 |
45 |
BM |
NA |
NA |
NA |
NA |
Bio |
NO |
BCS |
NA |
NO |
T2N0MX |
4,5 |
NA |
SCNC |
- |
+ |
- |
- |
NA |
NA |
<1 |
NED |
|
Yalcin[27] |
1997 |
63 |
BM |
BM |
BM |
Neg |
NA |
Bio |
NO |
Mast + ALND |
NO |
NO |
T2N0M0 |
5 |
0/? |
NET |
+ |
NA |
NA |
NA |
NA |
NA |
18 |
NED |
|
Fukunaga[28] |
1998 |
51 |
BM |
Neg |
BM |
Neg |
NO |
NA |
NA |
Mast + ALND |
NA |
NA |
T2N0M0 |
2,5 |
0/29 |
NET |
+ |
- |
+ |
- |
- |
NA |
16 |
NED |
|
Fukunaga[29] |
1998 |
38 |
BM |
BM |
BM |
Neg |
NO |
NA |
NO |
Mast + ALND |
NO |
NO |
T2N1M0 |
2,5 |
1/7 |
NEC |
+ |
+ |
- |
- |
- |
12% |
72 |
NED |
|
Sebenik[30] |
1998 |
67 |
NA |
NA |
NA |
NA |
NA |
NA |
Yes |
Mast + ALND |
NA |
NA |
T2NXM0 |
4 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
33 |
NED |
|
Samli[31] |
2000 |
60 |
PBM |
BM |
BM |
Neg |
NO |
Bio |
Yes |
Mast + ALND |
CDDP/VP-16+ 5-FU/CPA/EPI |
Yes |
T4N1M0 |
4,5 |
10/11 |
SCNC |
+ |
+ |
+ |
+ |
NA |
NA |
6 |
AWD |
|
Yamasaki[32] |
2000 |
41 |
BM |
Neg |
SBM |
Neg |
Sus |
Cit |
NO |
Mast + ALND |
CPA/MTX/5-FU |
NO |
T2N0M0 |
3,5 |
0/5 |
SCNC |
+ |
- |
- |
- |
NA |
NA |
16 |
NED |
|
Hoang[33] |
2001 |
41 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
T3NXMX |
14,5 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
|
51 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
T3NXMX |
8 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
||
|
Salmo[34] |
2001 |
46 |
NA |
NA |
NA |
NA |
NA |
NA |
NO |
BCS |
ChT |
YES |
T2N0M0 |
4 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
9 |
NED |
|
Berruti[35] |
2004 |
59 |
LMet |
Neg |
Neg |
LMet |
NO |
NA |
Yes |
LMet resection |
Tam |
NO |
TXNXM1 |
NA |
NA |
NEC |
+ |
+ |
+ |
- |
- |
12 |
144 |
NED |
|
Bigotti[36] |
2004 |
56 |
CM |
BM |
BM |
NA |
Neg |
Bio |
Yes |
NO |
ChT + Som |
NO |
T3N1M0 |
18 |
2/9 |
SCNC |
- |
+ |
- |
- |
- |
NA |
15 |
DOD |
|
Bergman[37] |
2004 |
61 |
BL |
BM |
BM |
Neg |
Neg |
Bio |
NO |
Mast + ALND |
NO |
NO |
T2N1M0 |
2,5 |
2/5 |
SCNC |
- |
- |
- |
- |
- |
- |
NA |
NA |
|
Jochems[38] |
2004 |
71 |
BM |
NA |
BM |
Neg |
Neg |
Bio |
NO |
Mast + ALND |
Tam |
NO |
T2N0M0 |
3 |
0/10 |
NEC |
+ |
+ |
+ |
+ |
- |
NA |
12 |
NED |
|
Mariscal[39] |
2004 |
53 |
BM, SR, N+ |
HyBM |
BM, N+ |
Neg |
Neg |
Bio |
Yes |
BCS + ALND |
HoT |
NO |
T3N1M0 |
5,5 |
1/? |
SCNC |
NA |
+ |
NA |
NA |
NA |
NA |
6 |
NED |
|
Sridhar[40] |
2004 |
58 |
NA |
NA |
NA |
NA |
NA |
NA |
NO |
BCS |
ChT |
YES |
T2N1M0 |
2 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
18 |
NED |
|
Yamamoto [41] |
2004 |
53 |
NA |
NA |
NA |
Neg |
Neg |
NA |
NO |
NA |
NO |
NO |
T3N2M0 |
6,5 |
NA |
NA |
NA |
NA |
- |
NA |
NA |
NA |
34 |
NED |
|
75 |
NA |
NA |
NA |
Neg |
Neg |
NA |
NO |
NA |
CPA/MTX/5-FU + HoT |
NO |
T2N1M0 |
2,5 |
NA |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
43 |
NED |
||
|
Adegbola[42] |
2005 |
46 |
BL |
NA |
NA |
Neg |
NO |
NO |
NO |
BCS |
CDDP/VP-16+ |
Yes |
T1NXM0 |
1 |
0 |
SCNC |
+ |
+ |
- |
NA |
- |
NA |
48 |
NED |
|
60 |
BM |
NA |
NA |
Neg |
NO |
NO |
NO |
BCS |
CDDP/VP-16+ |
Yes |
T1NxM0 |
1,7 |
0 |
SCNC |
+ |
+ |
- |
NA |
- |
NA |
20 |
DOD |
||
|
61 |
BM, N+ |
NA |
NA |
Neg |
NO |
NO |
NO |
BCS |
CDDP/VP-16+ |
Yes |
T1NxM1 |
1,7 |
0 |
SCNC |
+ |
- |
- |
NA |
- |
NA |
6 |
AWD |
||
|
Stein[43] |
2005 |
54 |
BM, N+ |
NA |
NA |
NA |
NA |
Bio |
Yes |
Mast + ALND |
NO |
Yes |
T1N1M0 |
1,5 |
5/15 |
SCNC |
+ |
NA |
- |
NA |
NA |
NA |
24 |
NED |
|
Tsai[44] |
2005 |
42 |
BM |
NA |
NA |
Neg |
NA |
Bio |
NA |
Mast |
NA |
NA |
NA |
NA |
NA |
NEC |
+ |
+ |
+ |
+ |
NA |
NA |
NA |
NA |
|
Fujimoto[45] |
2007 |
40 |
BL, BND |
HyBM |
Neg |
NO |
NO |
Bio |
NO |
Mast + SLNB |
Ana |
NO |
T2(m)N0 M0 |
2 |
0/1 |
NEC |
+ |
+ |
+ |
NA |
+ |
NA |
NA |
NA |
|
Hennessy[46] |
2007 |
63 |
PAMet |
Neg |
Neg |
BMet PAMet |
NO |
Bio |
NO |
Mast + SLNB |
ChT/Tam |
NO |
TXNXM1 |
NA |
NA |
NEC |
+ |
+ |
NA |
NA |
NA |
NA |
NA |
AWD |
|
Kitakata[47] |
2007 |
44 |
BL |
HyBM |
BM |
BM |
Neg |
Neg |
NO |
Mast + ALND |
CPA/Epi + DTX |
NO |
T2N1M0 |
4,5 |
2/15 |
SCNC |
- |
+ |
- |
+ |
- |
NA |
22 |
NED |
|
La Rosa[48] |
2007 |
49 |
BL |
Pos |
Pos |
NO |
NO |
Cit |
NO |
Mast |
ChT |
NO |
T2NXMX |
2,5 |
NA |
NEC |
+ |
+ |
+ |
+ |
- |
NA |
NA |
NA |
|
Vidulich[49] |
2007 |
76 |
BM, N+, PE |
BM, N+ |
NA |
LMet |
MMet |
Cit, Bio |
NO |
NO |
Oct/Ever, Bev/Erl |
NO |
T4N1M1 |
5 |
NA |
NEC |
+ |
+ |
+ |
+ |
- |
NA |
NA |
AWD |
|
Yaren[50] |
2007 |
76 |
NA |
NA |
NA |
Neg |
NA |
NA |
NO |
Mast + ALND |
HoT |
NO |
T2N0M0 |
5 |
0/13 |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
12 |
NED |
|
Jeong[51] |
2008 |
39 |
BL |
IBM |
HypBM |
NO |
NO |
NO |
NO |
Mast + ALND |
ChT / Hot |
Yes |
T2N1M1 |
2,2 |
2/14 |
NEC |
+ |
+ |
+ |
+ |
NA |
NA |
32 |
NED |
|
Kim[52] |
2008 |
27 |
BM |
HeBM |
BM |
Neg |
Neg |
Bio |
NO |
BCS + ALND |
ChT |
Yes |
T2NXM0 |
3,2 |
NA |
NEC |
+ |
+ |
- |
NA |
NA |
NA |
18 |
NED |
|
Kinoshita[53] |
2008 |
31 |
BL |
HyBM |
Neg |
MMet |
NO |
Bio |
Yes |
Mast + ALND |
CDDP/CPT-11 |
NO |
T2N1M1 |
3,7 |
7/30 |
SCNC |
+ |
+ |
- |
+ |
- |
NA |
1 |
AWD |
|
Lopez Garcia[54] |
2008 |
31 |
NA |
NA |
NA |
NA |
Neg |
NA |
NO |
Mast + ALND |
NO |
YES |
T3N1MX |
10 |
2/15 |
NA |
NA |
NA |
- |
NA |
NA |
NA |
15 |
DOD |
|
Mecca[55] |
2008 |
70 |
PLM |
NA |
NA |
NA |
NO |
NA |
NO |
BCS + SLNB |
NO |
NO |
T4N1M0 |
1,9 |
2/2 |
NEC |
NA |
+ |
+ |
+ |
+ |
NA |
12 |
NED |
|
Ogawa[11] |
2008 |
34 |
BM |
HeBM |
HypBM |
Neg |
NA |
Bio |
NA |
BCS |
NA |
NA |
T2NXM0 |
2,7 |
NA |
NET |
+ |
- |
+ |
+ |
NA |
NA |
7 |
NED |
|
Pagani[56] |
2008 |
62 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
BCS + ALND |
NA |
NA |
T1N2MX |
1,5 |
19/20 |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
NA |
NA |
|
41 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
Mast + ALND |
NA |
NA |
T2N1MX |
4,1 |
1/18 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
||
|
Sadanaga[57] |
2008 |
33 |
NA |
NA |
NA |
NA |
NA |
NA |
Yes |
Mast ALND |
ChT |
YES |
T2N0M0 |
4 |
0/? |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
60 |
NED |
|
Ulamec[58] |
2008 |
60 |
Hematuria |
BM |
NA |
NA |
NA |
NA |
Yes |
Mast + ALND |
HoT |
Yes |
T4N2M1 |
4,5 |
9/9 |
NEC |
- |
+ |
+ |
+ |
+ |
5% |
18 |
NED |
|
Akhtar[59] |
2009 |
40 |
BL, N+ |
NA |
NA |
NA |
NA |
Cit, Bio |
NA |
Mast + ALND |
NA |
NA |
T3NXMX |
8,5 |
NA |
NEC |
NA |
+ |
NA |
NA |
NA |
NA |
NA |
NA |
|
Burckhardt[60] |
2009 |
84 |
NA |
NA |
NA |
NA |
NA |
NA |
Yes |
Mast + ALND |
HoT |
NO |
T2N1M0 |
3 |
+/? |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
NA |
NED |
|
El Hassani[61] |
2009 |
40 |
BM |
NA |
BM |
Neg |
NO |
Bio |
Yes |
NO |
VP16-CDDP |
NA |
T4NXMX |
NA |
NA |
NEC |
+ |
+ |
+ |
+ |
NA |
NA |
1 |
DOD |
|
Ersahin[62] |
2009 |
50 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
BCS |
NA |
NA |
T3NXM0 |
2,5 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
12 |
NED |
|
Haji[63] |
2009 |
68 |
NA |
NA |
NA |
NA |
NA |
NA |
YES |
Mast + ALND |
NO |
NO |
T3N1M0 |
5,8 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
6 |
DOD |
|
Hojo[64] |
2009 |
60 |
NA |
NA |
NA |
NA |
NA |
NA |
NO |
Mast + ALND |
NO |
NO |
T3N0M1 |
3 |
0/? |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
26 |
AWD |
|
Lee[65] |
2009 |
65 |
BM |
HyBM |
HypBM |
NO |
Neg |
Neg |
NO |
BCS + SLNB |
HoT |
NO |
T1N0M0 |
1,6 |
0/1 |
NEC |
NA |
+ |
+ |
- |
- |
NA |
NA |
NED |
|
Okoshi[66] |
2009 |
63 |
BM |
HyBM |
HypBM |
Neg |
No |
Cit |
NO |
BCS + ALND |
ChT |
Yes |
T2N0M0 |
2 |
0/? |
NET |
- |
+ |
- |
- |
+ |
NA |
44 |
NED |
|
Rivero[67] |
2009 |
41 |
NA |
NA |
NA |
NA |
NA |
NA |
YES |
BCS |
NO |
Yes |
T3N0M0 |
6 |
0/? |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
20 |
NED |
|
Rineer[68] |
2009 |
81 |
NA |
NA |
NA |
NA |
NA |
NA |
YES |
BCS |
NO |
Yes |
T3N1M0 |
5 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
26 |
AWD |
|
Salama[69] |
2009 |
48 |
BoMet |
NA |
NA |
NA |
NA |
NA |
YES |
NO |
NO |
NO |
T4NXMX |
2,5 |
NA |
NA |
+ |
+ |
NA |
NA |
NA |
NA |
<1 |
AWD |
|
Sartori[70] |
2009 |
70 |
NA |
NA |
NA |
NA |
Neg |
NA |
NO |
BCS + ALND |
Som |
Yes |
T1N3M0 |
1,8 |
34/? |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
12 |
NED |
|
Stita[71] |
2009 |
64 |
BM |
BM |
BM |
Neg |
NO |
NA |
NO |
Mast + ALND |
ChT |
NO |
T2N0M0 |
3 |
0/? |
NET |
+ |
+ |
+ |
+ |
NA |
NA |
8 |
NED |
|
Yamaguchi[72] |
2009 |
51 |
BM |
BM |
BM |
NA |
Neg |
Bio |
NO |
Mast + ALND |
PTX |
NO |
T2N0M0 |
2,5 |
NA |
SCNC |
+ |
+ |
- |
- |
- |
85% |
12 |
AWD |
|
Christie[73] |
2010 |
61 |
NA |
NA |
NA |
NA |
NA |
NA |
NO |
BCS |
NO |
NO |
T3N2M0 |
3 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
3 |
DOD |
|
Goucha[74] |
2010 |
40 |
NA |
NA |
NA |
NA |
NA |
NA |
NO |
BCS + ALND |
NO |
Yes |
T1N0MX |
1,8 |
0/15 |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
12 |
NED |
|
Honami[75] |
2010 |
54 |
BND |
HyBM |
Neg |
NO |
No |
Bio |
NO |
BCS |
HoT |
Yes |
T1NXMX |
1,5 |
NA |
ICNE |
+ |
+ |
+ |
NA |
- |
NA |
18 |
NED |
|
Huettemann [76] |
2010 |
65 |
NA |
NA |
NA |
Neg |
Neg |
NA |
NO |
Mast + ALND |
DTX/Bev |
NO |
T3N1M1 |
9 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
|
Latif[77] |
2010 |
53 |
BM |
Neg |
BM |
NO |
Neg |
Cit, Bio |
Yes |
BCS + SLNB |
Tam/Som |
Yes |
T3N0M0 |
1 cm |
0/1 |
SCNC |
+ |
+ |
- |
NA |
- |
NA |
NA |
NA |
|
Saglam[78] |
2010 |
60 |
NA |
NA |
NA |
NA |
Neg |
NA |
NO |
NO |
NO |
NO |
T4N1M1 |
0,6 |
1/1 |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
26 |
DOD |
|
Salman[79] |
2010 |
72 |
NA |
NA |
NA |
Neg |
Neg |
NA |
NO |
Mast + ALND |
Letr |
NO |
TXNXM1 |
NA |
NA |
NA |
NA |
NA |
+ |
NA |
NA |
NA |
12 |
NED |
|
Buttar[80] |
2011 |
63 |
Jaundice |
NA |
NA |
Pos |
NO |
Bio |
NO |
NO |
Tam/Ana |
NO |
T2N0M1 |
NA |
0/1 |
NEC |
- |
+ |
+ |
NA |
- |
NA |
12 |
NED |
|
Cesaretti[81] |
2011 |
68 |
BM, N+ |
BL |
HypBM |
NA |
NA |
Cit, Bio |
NO |
BCS + ALND |
ADR/CPA + Ana |
Yes |
T1cN0Mx |
1,1 |
0/19 |
NEC |
+ |
+ |
+ |
+ |
- |
7% |
34 |
NED |
|
Ghanem[82] |
2011 |
64 |
BM, N+ |
BN |
BN |
Neg |
NA |
Bio |
Yes |
Mast + ALND |
ADR/CPA + Ana |
YES |
T3N2M0 |
8 |
16/23 |
NA |
+ |
NA |
+ |
+ |
- |
10% |
32 |
AWD |
|
Jach[83] |
2011 |
28 |
BL |
BN |
NA |
NA |
NA |
Bio |
NO |
BCS + ALND |
ADR + Tam |
YES |
T1N0M0 |
1,1 |
0/4 |
ICNE |
+ |
NA |
+ |
+ |
NA |
40% |
NA |
NA |
|
Kavasaki[84] |
2011 |
43 |
BND |
BM |
NA |
NA |
NA |
NA |
NO |
BCS |
NA |
NA |
T1N0M0 |
1,2 |
0/4 |
NEC |
+ |
+ |
+ |
NA |
+ |
NA |
NA |
NA |
|
Kawanishi [85] |
2011 |
67 |
UBM |
HyBM |
BM |
NA |
NA |
Cit, Bio |
NO |
BCS + SLNB |
Ana |
NO |
T1N0M0 |
0,8 |
0/1 |
NEC |
+ |
+ |
+ |
NA |
- |
NA |
12 |
NED |
|
Navrozoglou[86] |
2011 |
73 |
NO |
BN |
BN |
NA |
Neg |
Bio |
NO |
Mast + ALND |
NO |
NO |
T1N0M0 |
1,1 |
0/17 |
NET |
+ |
+ |
NA |
NA |
NA |
NA |
48 |
NED |
|
Nicoletti[87] |
2011 |
40 |
BM |
BN |
BN |
Neg |
NO |
Bio |
NO |
Mast + ALND |
ADR/CPA + CBL/VP-16 + Tam/LHRH |
NO |
T2N1M0 |
3 |
1/16 |
SCNC |
+ |
+ |
+ |
+ |
- |
+ |
96 |
NED |
|
Nozoe[88] |
2011 |
57 |
BL |
HyBM |
BM |
NA |
NA |
NA |
NO |
Mast + ALND |
CMF + AI |
NA |
NA |
3 |
0/? |
NEC |
NA |
+ |
+ |
+ |
- |
NA |
NA |
NA |
|
Zhang[89] |
2011 |
29 |
BND |
BM |
BM |
NO |
NO |
Cit |
NO |
BCS + SLNB |
CPA/EPI/5-FU + DTX + Tor |
NA |
T2N0M0 |
2 |
0/2 |
NET |
+ |
+ |
+ |
+ |
- |
1% |
20 |
NED |
|
Alkaied[90] |
2012 |
83 |
Anorexia |
Neg |
Neg |
NO |
Pos |
Bio |
Yes |
NO |
Letr - Ana |
NA |
TXNXM1 |
NA |
NA |
SCNC |
- |
+ |
+ |
NA |
NA |
NA |
12 |
NED |
|
Flessas[91] |
2012 |
59 |
NO |
NA |
Mic |
NO |
NO |
Bio |
NO |
BCS +ALND |
NA |
NA |
T2N1M0 |
2,8 |
1/? |
ICNE |
+ |
+ |
NA |
NA |
NA |
NA |
NA |
NA |
|
Graça[92] |
2012 |
83 |
BM |
BN |
BM |
Neg |
Neg |
Cit |
NO |
BCS + SLNB |
HoT |
NO |
T2N0M0 |
2,4 |
0/1 |
NEC |
NA |
+ |
+ |
NA |
NA |
NA |
NA |
NED |
|
Menéndez [93] |
2012 |
44 |
NO |
NA |
BM |
NA |
NA |
NA |
NO |
BCS + ALND |
5-FU/EPI/CPA |
Yes |
T2N0M0 |
2 |
1/? |
NEC |
NA |
NA |
+ |
+ |
- |
NA |
48 |
NED |
|
68 |
NO |
NA |
BM |
NA |
NA |
NA |
NO |
BCS + SLNB |
5-FU/EPI/CPA + DTX + Ana |
Yes |
|
3,6 |
NA |
NEC |
+ |
NA |
NA |
NA |
NA |
NA |
24 |
NED |
||
|
58 |
NO |
NA |
BM |
NO |
NO |
Bio |
NO |
BCS + SLNB |
5-FU/EPI/CPA |
Yes |
T1N0M0 |
1 |
0/1 |
NEC |
NA |
NA |
+ |
- |
- |
NA |
8 |
AWD |
||
|
69 |
NO |
HyBM |
BM |
NA |
NA |
NA |
NA |
BCS + SLNB |
NA |
NA |
T1N0M0 |
1,4 |
0/1 |
ICNE |
+ |
+ |
+ |
+ |
- |
10% |
2 |
NED |
||
|
Miura[94] |
2012 |
72 |
NO |
NA |
NA |
Neg |
NA |
Cit, Bio |
NO |
BCS + SLNB |
NA |
NA |
|
1,5 |
0/1 |
NEC |
+ |
+ |
+ |
+ |
- |
1% |
NA |
NA |
|
Psoma[95] |
2012 |
46 |
BM |
HyBM |
HypBM |
Neg |
NO |
NA |
NO |
Mast + ALND |
CDDP/EPI/VP-16 |
Yes |
T3N0M0 |
6,5 |
NA |
NET |
+ |
+ |
NA |
NA |
NA |
NA |
6 |
NED |
|
Su[96] |
2012 |
75 |
PBM |
HyBM |
HypBM |
Neg |
NA |
Bio |
NO |
Mast + ALND |
Let |
NO |
T2N0M0 |
4 |
0/? |
ICNE |
+ |
+ |
+ |
+ |
- |
NA |
20 |
NED |
|
Watrowski [97] |
2012 |
56 |
BM |
HyBM |
NA |
NO |
NO |
Bio |
NO |
BCS + SLNB |
CPA/EPI/5-FU + HoT |
Yes |
T1N0M0 |
1,7 |
0/1 |
NET |
NA |
+ |
- |
- |
- |
46% |
15 |
NED |
|
Yavas[98] |
2012 |
77 |
BM, N+ |
BM |
HypBM |
Neg |
NO |
NA |
NO |
Mast + ALND |
NO |
NO |
T2N1M0 |
3 |
5/16 |
ICNE |
NA |
+ |
+ |
+ |
+ |
NA |
15 |
NED |
|
Abbasi[99] |
2013 |
37 |
BL, N+ |
NA |
NA |
BoMet |
NA |
Bio |
NO |
Mast + ALND |
5-FU/ADR/CPA + CDDP + VP-16 |
NO |
T3N2M1 |
7,5 |
9/19 |
ICNE |
+ |
+ |
NA |
NA |
NA |
NA |
6 |
NED |
|
Angarita[100] |
2013 |
51 |
BL |
Neg |
SBM |
Neg |
NO |
Bio |
Yes |
BCS + ALND |
CDDP/VP-16 + PTX |
NA |
T2N0M0 |
3,2 |
0/? |
ICNE |
+ |
+ |
- |
NA |
- |
>20% |
13 |
AWD |
|
Chang[101] |
2013 |
42 |
BL |
MBM |
HypBM |
NO |
Neg |
Cit |
No |
NO |
NA |
NA |
T2N1M0 |
NA |
+/? |
NEC |
+ |
+ |
+ |
NA |
- |
NA |
NA |
NA |
|
Hanna[102] |
2013 |
60 |
PBM |
Neg |
Neg |
Neg |
NO |
Bio |
NO |
BCS |
CBL/VP-16 |
NO |
T1N2M0 |
1,4 |
4/11 |
NEC |
- |
+ |
+ |
NA |
- |
NA |
NA |
NA |
|
Senetta[103] |
2013 |
82 |
Asthenia |
BM |
NA |
PiMet |
NO |
Bio |
NO |
BCS + SLNB |
HoT |
NO |
T1NXM1 |
2,3 |
NA |
NEC |
+ |
+ |
+ |
+ |
- |
10 |
NA |
NA |
|
Yoon[8] |
2013 |
44 |
BM |
HyBM |
HyBM |
Neg |
Neg |
Bio |
NA |
Mast + ALND |
CPA/ADR |
NA |
T2NXM0 |
2 |
NA |
NEC |
+ |
+ |
+ |
+ |
NA |
NA |
2 |
NED |
|
Cinkir[104] |
2014 |
75 |
BM |
BM |
BM |
NA |
NA |
Bio |
NO |
Mast + ALND |
CDDP/VP-16 |
Yes |
T0N0M0 |
0 |
0/? |
SCNC |
+ |
+ |
+ |
+ |
- |
5% |
30% |
NED |
|
2014 |
77 |
PBM |
SBM |
SBM |
NA |
NA |
Bio |
NO |
Mast + ALND |
AI |
NO |
T2NXM0 |
2,3 |
NA |
NEC |
+ |
+ |
+ |
+ |
- |
10% |
9% |
NED |
|
|
Pagano[105] |
2014 |
51 |
BL, NR |
NA |
BM |
Neg |
NA |
Bio |
NO |
Mast + ALND |
CPA/MTX/5-FU + Tam |
NA |
T2N2M0 |
3,5 |
5/28 |
NET |
+ |
+ |
+ |
+ |
- |
30 |
126 |
AWD |
|
Suhani[106] |
2014 |
66 |
BL |
NA |
NA |
Neg |
NA |
Bio |
NO |
Mast + ALND |
CPA/ADR/5-FU + AI |
Yes |
T3N1M0 |
6,5 |
1/15 |
NET |
+ |
- |
+ |
+ |
- |
NA |
48 |
NED |
|
55 |
BL |
NA |
NA |
Neg |
NA |
Bio |
NO |
Mast + ALND |
CPA/ADR/5-FU + AI |
Yes |
T2N1M0 |
4,5 |
2/16 |
NET |
+ |
- |
+ |
- |
- |
NA |
36 |
NED |
||
|
50 |
BL |
NA |
NA |
Neg |
NA |
Bio |
NO |
Mast + ALND |
CPA/ADR/5-FU + AI |
Yes |
T2N0M0 |
4 |
0/18 |
NET |
+ |
+ |
+ |
+ |
- |
NA |
18 |
NED |
||
|
60 |
BL, BND |
NA |
NA |
Neg |
NA |
Bio |
NO |
Mast + ALND |
CPA/ADR/5-FU + AI |
Yes |
T3N1M0 |
5,5 |
1/16 |
NET |
- |
+ |
+ |
+ |
- |
NA |
9 |
NED |
||
|
Janosky[107] |
2015 |
34 |
BL |
Neg |
HypBM |
NA |
Neg |
Bio |
Yes |
BCS + ALND |
CBL/PTX |
Yes |
T2N0M0 |
3,5 |
0/? |
NEC |
+ |
+ |
- |
NA |
- |
100% |
2 |
AWD |
|
Kawasaki[108] |
2015 |
60 |
SR |
HyBM |
NA |
Neg |
NO |
Bio |
NO |
BCS + ALND |
Ana |
NO |
T1N0M0 |
1,2 |
0/4 |
NEC |
+ |
- |
+ |
NA |
0 |
6.3% |
48 |
AWD |
|
Rana[109] |
2015 |
65 |
BL |
NA |
NA |
Neg |
NO |
Bio |
NA |
Mast + ALND |
NA |
NA |
T3N2M0 |
6 |
4/20 |
NEC |
+ |
+ |
+ |
+ |
- |
NA |
NA |
NA |
|
Santos-Juanez[110] |
2015 |
80 |
BM |
Neg |
Neg |
Pos |
NO |
Bio |
Yes |
NO |
NO |
Yes |
T4NXM1 |
17 |
NA |
NET |
+ |
+ |
+ |
+ |
- |
10% |
5 |
NED |
|
Sherwell-Cabello[111] |
2015 |
60 |
BL, N+ |
NA |
NA |
NA |
Neg |
NA |
NO |
Mast + ALND |
CBL/VP-16 |
Yes |
T3N3M0 |
6 |
11/15 |
NET |
- |
+ |
- |
- |
- |
70% |
6 |
NED |
|
Wei[112] |
2015 |
43 |
BM |
HyBM |
MBM |
NO |
NO |
Bio |
Yes |
Mast + ALND |
NA |
NA |
T2N1M0 |
3 |
1/? |
NET |
+ |
+ |
+ |
- |
+ |
10% |
NA |
NA |
|
Alva[113] |
2016 |
53 |
BL |
Neg |
SBM |
Neg |
NO |
Cit |
NO |
Mast + ALND |
NA |
NA |
T2N0M0 |
5 |
0/10 |
NEC |
+ |
+ |
- |
NA |
- |
NA |
|
|
|
Christensen [114] |
2016 |
73 |
SR |
BM |
BM |
PaMet |
NA |
NA |
NA |
BCS + ALND |
NA |
NA |
T2N3M1 |
3,8 |
18/21 |
ICNE |
- |
+ |
NA |
NA |
NA |
|
4,5 |
AWD |
|
D'antonio [115] |
2016 |
50 |
BL |
BL |
Neg |
Neg |
Neg |
Bio |
NO |
BCS + ALND |
NO |
NO |
T1N0M0 |
1,5 |
0/? |
ICNE |
+ |
+ |
- |
+ |
- |
<5% |
12 |
NED |
|
Mečiarová[116] |
2016 |
42 |
BL |
HyBM |
HypBM, Mic |
Neg |
NA |
NA |
NO |
BCS + SLNB |
VP-16/CDDP |
Yes |
T2N1M0 |
3,2 |
1/1 |
NEC |
+ |
+ |
- |
- |
- |
50% |
36 |
NED |
|
Nakai[117] |
2016 |
46 |
PBM |
HyBM, N+ |
NA |
Neg |
NA |
Bio |
NO |
Mast + ALND |
CPA/EPI/5-FU |
NA |
T2N2M0 |
2,3 |
9/17 |
NET |
+ |
+ |
+ |
+ |
+ |
61% |
4 |
NED |
|
Takanami [118] |
2016 |
57 |
Neuralgia |
NA |
NA |
Pos |
NA |
Bio |
NA |
Mast + ALND |
NA |
NA |
T2N0M0 |
NA |
NA |
NET |
NA |
NA |
NA |
NA |
NA |
NA |
180 |
AWD |
|
Abou Dalle[119] |
2017 |
47 |
NO |
NA |
BM |
NO |
Neg |
Bio |
NO |
Mast + SLNB |
CDDP/VP-16 + 5-FU/EPI/CPA + Tam |
NO |
T2N0M0 |
3 |
0/4 |
SCNC |
+ |
+ |
+ |
NA |
- |
50% |
10 |
NED |
|
Maqsood [120] |
2017 |
67 |
Neuralgia |
HyBM |
BM |
MMet |
MMet |
Bio |
Yes |
NO |
Let + Palb |
NO |
T1NXM1 |
1 |
|
NEC |
- |
+ |
+ |
NA |
- |
NA |
3 |
AWD |
|
Soe[121] |
2017 |
57 |
BL |
HyBM |
HypBM |
NA |
BoMet |
NA |
NO |
BCS |
CDDP/VP-16 + Oct |
NO |
T2NXM1 |
4 |
NA |
NET |
+ |
+ |
+ |
+ |
NA |
15% |
18 |
NED |
Headings: NA = Not available data; Clin Pres = Clinical presentation; US = breast Ultrasound; MX = mammography; Bio = biopsy; Cit = citology; Ad treat = adjuvant treatment (chemotherapy and/or hormone therapy); Adj RT = adjuvant radiotherapy; Tum size = tumor size (centimeters); LNs = lymph nodes removed; CrA = Chromogranin A; Syn = Synaptophisin; ER = Estrogen receptor; PR = Progesterone receptor; Her2 = her2-neu receptor; FUP = follow-up (months)
Clinical and radiological findings: Pos = positive for malignancy; Neg = negative for malignancy; BM = Breast Mass; CM = carcinomatous mastitis; N+ = axillary adenopathy, PBM = Painful breast mass; BL = breast lump; SR = Skin retraction, NR = nipple retraction, PLM = Paget-like Mass; BND = Bloody nipple discharge; UBM = Ulcerated Breast Mass; MBM = Multilobulated breast mass; HyBM = Hypoechoic (US) / Hypodense (MX) breast mass; Hyp = Hyperechoic (US) / Hyperdense breast mass = HeBM = Heterogeneous breast mass, SBM = Spiculated breast mass, Mic = microcalcifications, BoMet = Bone Metastases; LMet = Lung metastasis; PAMet = Perianal metastases, PiMet = Pituitary metastases; PaMet = Pancreatic metastases; PE = Pleural effusion; MMet = Multiple metastases; IBM = Isoechoic breast mass
Neg = Negative; Sus = suspicious; LMet = lung metastasis
Mast = Mastectomy; BCS = Breast Conservative Surgery; SLNB = Sentinel Lymph Node Biopsy; ALND = Axillary Lymph Node Dissection
Chemotherapy: ChT = chemotherapy (not defined); HoT = hormone therapy (not defined); CDDP = Cisplatin, CBL = Carboplatin, VP-16 = Etoposide, CPT-11 = Irinotecan, 5-FU = Fluorouracil, EPI = Epirubicin, CAP = Capecitabine, DTX = Docetaxel, 5’-DFUR = 50 deoxy-5-fluorouridine, Tor = Toremifene, CPA = Cyclophosphamide, EPI = Epirubicin, Tam = Tamoxifen, Tor = Torenifene, Let = Letrozole, S = Streptozotocin, MTX = Methotrexate, Ana = Anastrazole, AI = Aromatase inhibitor, LHRH = Leutinising hormone releasing hormone analogue, UFT = Uracil & Tegafur, PTX = Paclitaxel, ADR = Adriamycin (Doxorubicin), Sando = Sandostatin, Som = Somatostatin; Ever = Everolimus, Bev = Bevacizumab, Erl = Erlotinib; Palb = Palbociclib; Oct = Octreotide
Histology: SCNC = Small Cell Neuroendocrine Carcinoma, ICNE = Invasive carcinoma with neuroendocrine differentiation; NET = well-differentiated neuroendocrine tumor; NEC = poorly differentiated neuroendocrine carcinoma
Follow-Up: NED = No evidence of disease; AWD = Alive with disease; DOD = Died of disease; DUC = Died of Uncertain cause
†Median follow-up