Table 1: Presence of CTCs at baseline according to clinical-pathological variables.
|
All patients |
Patients without CTCs |
Patients with CTCs |
P-value |
|
(n = 47) |
(n = 9 )* |
(n = 36 )* |
|
|
n (%) |
n (%) |
n (%) |
|
Age (years) |
|
|
|
|
Mean ± SD |
54.4 ± 9.8 |
57 ± 8.2 |
53.8 ± 10.1 |
0.314a |
Range |
33-71 |
47-69 |
33-71 |
|
Tumor stage |
|
|
|
|
pT1 |
34 (72.3) |
7 (77.8) |
27 (75.0) |
0.730b |
pT2 |
7 (14.9) |
1 (11.1) |
5 (13.8) |
|
pT3 |
2 (4.3) |
0 |
2 (5.6) |
|
pT4 |
1 (2.1) |
- |
- |
|
Unknown |
3 (6.4) |
1 (11.1) |
2 (5.6) |
|
Nodal stage |
|
|
|
|
pN0 |
30 (63.8) |
4 (44.5) |
25 (69.4) |
0.163b |
pN1 |
7 (14.9) |
1 (11.1) |
6 (16.7) |
|
pN2 |
3 (6.4) |
0 |
2 (5.6) |
|
pN3 |
3 (6.4) |
2 (22.2) |
1 (2.7) |
|
Unknown |
4 (8.5) |
2 (22.2) |
2 (5.6) |
|
Histological grading |
|
|
|
|
G1 |
13 (27.7) |
3 (33.3) |
10 (27.7) |
0.738b |
G2 |
25 (53.2) |
5 (55.6) |
18 (50) |
|
G3 |
7 (14.9) |
1 (11.1) |
6 (16.7) |
|
unknown |
2 (4.2) |
0 |
2 (5.6) |
|
Histological type |
|
|
|
|
Ductal |
39 (83) |
5 (55.6) |
32 (88.8) |
0.562b |
Lobular |
5 (10.6) |
3 (33.3) |
2 (5.6) |
|
In situ |
3 (6.4) |
1 (11.1) |
2 (5.6) |
|
Hormone receptor status (ER, PgR) |
|
|
|
|
Negative |
5 (10.7) |
0 |
5 (13.8) |
0.299c |
Positive |
41 (87.2) |
9 (100) |
30 (83.5) |
|
Unknown |
1 (2.1) |
0 |
1 (2.7) |
|
Ki67** |
|
|
|
|
High |
13 (27.7) |
2 (22.2) |
10 (27.8) |
0.569c |
Low |
30 (63.8) |
6 (66.7) |
23 ( 63.9) |
|
Unknown |
4 (8.5) |
1 (11.1) |
3 (8.3) |
|
HER2 status |
|
|
|
|
Negative |
38 (80.9) |
6 (66.7) |
30 (83.4) |
0.246c |
Positive |
5 (10.6) |
2 (22.2) |
3 (8.3) |
|
Unknown |
4 (8.5) |
1 (11.1) |
3 (8.3) |
|
Type of surgery |
|
|
|
|
Breast conserving |
34 (72.4) |
7 (77.8) |
26 (72.2) |
0.550c |
Mastectomy |
13 (27.6) |
2 (22.2) |
10 (27.8) |
|
at-test
bCochran-Armitage test for trend (without unknowns when appropriate)
cχ2 test (without unknowns when appropriate)
* Total CTCs n = 45 (for two patients no CTCs samples were available) **ki67 was considered high (> 20%)