Table 1: Presence of CTCs at baseline according to clinical-pathological variables.

 

All patients

Patients without CTCs

Patients with CTCs

P-value

 

(n = 47)

(n = 9 )*

(n = 36 )*

 

 

n  (%)

n (%)

n (%)

 

Age (years)

 

 

 

 

   Mean ± SD

54.4 ± 9.8

57 ± 8.2

53.8 ± 10.1

0.314a

   Range

33-71

47-69

33-71

 

Tumor stage

 

 

 

 

   pT1

34 (72.3)

7 (77.8)

27 (75.0)

0.730b

   pT2

7 (14.9)

1 (11.1)

5 (13.8)

 

   pT3

2 (4.3)

0

2 (5.6)

 

   pT4

1 (2.1)

 -

-

 

   Unknown

3 (6.4)

1 (11.1)

2 (5.6)

 

Nodal stage

 

 

 

 

   pN0

30 (63.8)

4 (44.5)

25 (69.4)

0.163b

   pN1

7 (14.9)

1 (11.1)

6 (16.7)

 

   pN2

3 (6.4)

0

2 (5.6)

 

   pN3

3 (6.4)

2 (22.2)

1 (2.7)

 

   Unknown

4 (8.5)

2 (22.2)

2 (5.6)

 

Histological grading

 

 

 

 

   G1

13 (27.7)

3 (33.3)

10 (27.7)

0.738b

   G2

25 (53.2)

5 (55.6)

18 (50)

 

   G3

7 (14.9)

1 (11.1)

6 (16.7)

 

   unknown

2 (4.2)

0

2 (5.6)

 

Histological type

 

 

 

 

   Ductal

39 (83)

5 (55.6)

32 (88.8)

0.562b

   Lobular

5 (10.6)

3 (33.3)

2 (5.6)

 

   In situ

3 (6.4)

1 (11.1)

2 (5.6)

 

Hormone receptor status (ER, PgR)

 

 

 

 

   Negative

5 (10.7)

0

5 (13.8)

0.299c

   Positive

41 (87.2)

9 (100)

30 (83.5)

 

   Unknown

1 (2.1)

0

1 (2.7)

 

Ki67**

 

 

 

 

   High

13 (27.7)

2 (22.2)

10 (27.8)

0.569c

   Low

30 (63.8)

6 (66.7)

23 ( 63.9)

 

   Unknown

4 (8.5)

1 (11.1)

3 (8.3)

 

HER2 status

 

 

 

 

   Negative

38 (80.9)

6 (66.7)

30 (83.4)

0.246c

   Positive

5 (10.6)

2 (22.2)

3 (8.3)

 

   Unknown

4 (8.5)

1 (11.1)

3 (8.3)

 

Type of surgery

 

 

 

 

   Breast conserving

34 (72.4)

7 (77.8)

26 (72.2)

0.550c

   Mastectomy

13 (27.6)

2 (22.2)

10 (27.8)

 

at-test

bCochran-Armitage test for trend (without unknowns when appropriate)

cχ2 test (without unknowns when appropriate)

* Total CTCs n = 45 (for two patients no CTCs samples were available)  **ki67 was considered high (> 20%)