Type IV hypersensitivity reaction following Cyanoacrylate Glue Embolization (VenaSealTM) of the Great Saphenous Vein incompetence: A case report

Type IV hypersensitivity reaction following Cyanoacrylate Glue Embolization (VenaSealTM) of the Great Saphenous Vein incompetence: A case report

Author Info

Corresponding Author
Tjun Yip Tang
Department of Vascular Surgery, Singapore General Hospital, Singapore

A B S T R A C T

Background: In recent years, cyanoacrylate glue embolization (CAE) (VenaSealTM, Medtronic, Santa Rosa, USA) has emerged as an effective and safe strategy in the management of chronic venous insufficiency and varicose veins. The most common complication is a self-limiting post-procedure phlebitis, which often resolves in a few days. In rare instances, the rash persists for weeks and is believed be attributed to a delayed hypersensitivity reaction to cyanoacrylate. Method: We present a short report of a female patient who developed such a rash following CAE 3 weeks after VenaSeal treatment. Result: The patient made a complete self-limiting recovery of her rash after 2 weeks following expectant management with non-steroidal anti-inflammatories (NSAID) and analgesia. Conclusion: The VenaSealTM red skin reaction should be suspected in patients developing a rash post-CAE. This may be related to a delayed hypersensitivity reaction to the acrylate component of the compound.

Article Info

Article Type
Case Report
Publication history
Received: Tue 22, Jan 2019
Accepted: Fri 15, Feb 2019
Published: Thu 28, Feb 2019
Copyright
© 2023 Tjun Yip Tang . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.SCR.2019.01.009