Biochemical Clinical and Pathological Profile of Pancreatic Head Carcinoma in North Africa

Biochemical Clinical and Pathological Profile of Pancreatic Head Carcinoma in North Africa

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Feriel Sellam
National Research Center of Biotechnology CRBt, Constantine, Algeria

A B S T R A C T

Objective: A statistical clinical assessment of the effects of bilirubin and others hem catalyze biochemical parameters over the main signaling pathways involved in pancreatic head cancer to determine their carcinogenic impact using a molecular approach. Material and Methods: Patients’ data were collected at surgery department Sidi bel Abbes University Hospital (North Africa) patients were diagnosed with pancreatic cancer between 2013 and 2016. The data inclusion criteria were: Age, gender, medical history, surgical history, the year of diagnosis, as well as biological records such as: bilirubin, fibrinogen, creatinine and urea rates. Results: 44 patients with pancreatic cancer were included in our study (sex ratio=1.75). The mean age was 67.61 years. The most recorded medical history was diabetes with a rate of 43.2%, concerning surgical histories, 27.3% patients underwent a cholecystectomy. M1 was the most common diagnosis stage (27%). 81.81% of patients had hyperbilirubinemia, 6.81% had a normal bilirubinemia, 25% had high level of fibrinogen, 3.6% had a normal level. 77.3% had normal ureanemia, 18.2% had hyper-ureanemia and 15.9% had hypocreatininemia, 68.2% had normal level, 13.6% had hypercreatininemia. We matched patients’ groups with bilirubin level using Spearman’s correlation test and found a significant P value (P=0.015). We calculated the correlation between bilirubinemia and the stage of diagnosis, using the one-way ANOVA test and we found a significant P value (P=0.013). Conclusion: Our results represent an interesting shortcut to synthetize specific biochemical antibodies for bio-marking and diagnosis use, or even to lower serum level to reduce cancer aggressiveness.

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Article Type
Research Article
Publication history
Received: Wed 01, Jul 2020
Accepted: Fri 07, Aug 2020
Published: Fri 28, Aug 2020
Copyright
© 2023 Feriel Sellam. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JSO.2020.04.02