ApoL6: A Novel Biomarker of Apoptotic and Necroptotic Activity in Evolving STsegment Myocardial Infarction in Man

ApoL6: A Novel Biomarker of Apoptotic and Necroptotic Activity in Evolving STsegment Myocardial Infarction in Man

Author Info

Corresponding Author
Chien-An Andy Hu
Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA

A B S T R A C T

We have previously demonstrated that apolipoprotein L6 (ApoL6) is a pro-death, phospholipid-binding, BH3-only member of the Bcl-2 family. Ectopic expression of ApoL6 induces dichotomous cell death phenotype involving both apoptosis and necroptosis in various cell types. In addition, ApoL6 initiates inflammatory response that upregulates proinflammatory cytokines, such as IL-1β. In this study, we show elevated levels of ApoL6 in the sera of the majority of ST-segment myocardial infarction (STEMI) patients prior to reperfusion which is highly suggestive of the activation of apoptotic and/or necroptotic pathways in ruptured plaque. Thus, ApoL6 could serve as a biomarker specific for inflammatory apoptotic and/or necroptotic activity in STEMI, as well as other diseases.

Article Info

Article Type
Research Article
Publication history
Received: Wed 24, Jun 2020
Accepted: Fri 07, Aug 2020
Published: Mon 24, Aug 2020
Copyright
© 2023 Chien-An Andy Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JICOA.2020.04.10