Music and Dopamine – Potential in Movement Disorders

Music and Dopamine – Potential in Movement Disorders

Author Info

Corresponding Author
Ichiro Kawahata
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan


Most people have been deriving pleasure from music since long ago. Music is deeply associated with human communication and language. Music had also been popular as therapy in early history. How can we feel happiness or sadness when we listen to music? Scientifically, the dorsal and ventral striatum release dopamine when listening to pleasurable music. The activity in these structures is known to associate with the reward system of the human brain. Moreover, the nigrostriatal dopaminergic system regulates our motor function, and this is the very part that is damaged in the movement disorders. In this article, we review the potent role of music from the viewpoint of the dopaminergic system. We also describe the molecular mechanism of the dopaminergic pathogenesis and suggest the potent ability of music for the therapy of Parkinson's disease and related movement disorders.

Article Info

Article Type
Review Article
Publication history
Received: Fri 20, Mar 2020
Accepted: Thu 02, Apr 2020
Published: Tue 07, Apr 2020
© 2021 Ichiro Kawahata. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JBN.2020.01.02