Effect of reactive oxygen species on the ligand-independent activation of EGFR in tongue squamous cell carcinoma

Effect of reactive oxygen species on the ligand-independent activation of EGFR in tongue squamous cell carcinoma

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Corresponding Author
Feixin Liang
Department of Oral and Maxillofacial Surgery,Hospital of Stomatology,Guangxi Medical University,Nanning 530021,Guangxi, China

A B S T R A C T

Objective: To explore the expression of 8-hydroxy-2′-deoxyguanosine (8-OHdG), p-Src, and phosphorepidermal growth factor receptor (p-EGFR) and the effect of reactive oxygen species on ligand-independent activation of EGFR in tongue squamous cell carcinoma (TSCC) tissues. Methods: The expressions of 8-OHdG, EGFR, and p-EGFR in carcinoma tissues and carcinoma-adjacent tissues of 40 cases of TSCC were determined immunohistochemically. The correlations between 8-OHdG expression and p-Src and p-EGFR expressions were analyzed. Results: 8-OHdG, p-Src, and p-EGFR were highly expressed in TSCC tissues, with positivity rates of 82.5%, 70%, and 55%, respectively, whereas they were lowly expressed in carcinoma-adjacent tissues, with positivity rates of 17.5%, 12.5%, and 7.5%, respectively. The expressions of 8-OHdG, p-Src, and p-EGFR were significantly higher in carcinoma tissue than in carcinoma-adjacent tissue (P < 0.05), and statistically significant correlations were observed between 8-OHdG expression and p-Src and p-EGFR expressions (P < 0.05). Conclusion: This study preliminarily determined the expression of the reactive oxygen species-Src-EGFR signaling pathway in TSCC, providing clinical evidence for the use of cetuximab in combination with other chemotherapy drugs in the treatment of oral cancer.

Article Info

Article Type
Research Article
Publication history
Received: Sun 10, Jun 2018
Accepted: Fri 22, Jun 2018
Published: Fri 29, Jun 2018
Copyright
© 2023 Feixin Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.DOBCR.2018.02.005