Characteristics and Outcomes of Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis Depending on Malignancy Etiology

Author Info

Andréa Pastissier Jérôme Razanamahery Sébastien Humbert Thibaud Soumagne Etienne Daguindau Catherine Chirouze Gaël Piton Nadine Magy-Bertrand

Corresponding Author

Nadine Magy-Bertrand
Internal Medicine Department, Besancon University Hospital, Besancon, France

A B S T R A C T

Hemophagocytic lymphohistiocytosis (HLH) may be secondary to cancer or other conditions in adults. We aimed to compare characteristics and outcomes of secondary HLH depending on cancer status among adults. Weight loss over 10 %, headache and enlarged lymph nodes were more frequent in malignant- HLH (M-HLH). Higher phosphatase alkaline level and CRP level were present in M-HLH. Mortality rate tended to be higher in M-HLH group in the first month and during the two years follow-up. Some clinical features and biological abnormalities are associated with an increased probability of malignancy in secondary HLH among adults.

Article Info

Article Type

Research Article

Publication history

Received: Mon 11, Jul 2022
Accepted: Tue 02, Aug 2022
Published: Fri 12, Aug 2022

Copyright

© 2023 Nadine Magy-Bertrand. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2022.03.04