In Search of a Histopathological Pattern of Immune-Mediated Gastritis from Nivolumab Therapy: A Case Report with Literature Review

In Search of a Histopathological Pattern of Immune-Mediated Gastritis from Nivolumab Therapy: A Case Report with Literature Review

Author Info

Corresponding Author
Flor M Fernández-Gordón Sánchez
Division of Gastroenterology and Hepatology, Doce de Octubre University Hospital, Madrid, Spain

A B S T R A C T

Immunotherapy with checkpoint inhibitors is associated with termed inflammatory and immune-related side effects (irAE). Upper gastrointestinal symptoms are infrequent and appear mainly in patients on combination therapy with two checkpoint inhibitor drugs. We present the case of a patient with IIIB stage cutaneous melanoma treated with Nivolumab in monotherapy who developed an immune-mediated gastritis. Histopathologically, due to the paucity of published cases, no specific pattern of Nivolumab-immune-mediated gastritis has been described. We have reviewed the literature and compared the histopathology of the cases available in the literature.

Article Info

Article Type
Case Report and Review of the Literature
Publication history
Received: Tue 17, Aug 2021
Accepted: Thu 04, Nov 2021
Published: Thu 11, Nov 2021
Copyright
© 2023 Flor M Fernández-Gordón Sánchez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2021.10.03