Role of Circulating DNA in the Precocious Diagnosis of Lymphoma: an example in a Transplant-Related Aggressive Lymphoma

Author Info

Cristina Zucchinetti Edoardo Benedetti Elena Ciabatti Enrico Orciuolo Eugenio Mario Ciancia Federico Rossari Francesca Guerrini Francesco Caracciolo Gabriele Buda Luca Biavati Maria Immacolata Ferreri Mario Petrini Sara Galimberti Susanna Grassi Ugo Boggi

Corresponding Author

Federico Rossari
Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy

A B S T R A C T

We report the case of an aggressive non-Hodgkin lymphoma transmission from a live renal donor to her recipient. Soon after donation, the donor developed a high-grade B cell lymphoma, and the disease became evident also in the recipient three months thereafter, showing the same biological characteristics as confirmed by IgH rearrangement, karyotype and chimerism analyses. In the recipient, the IgH clone appeared in circulating cell free DNA (cfDNA), but not in peripheral blood nor in bone marrow, one month earlier than the imaging evidence of disease. This case supports the fundamental predictive role of molecular analysis of the plasma compartment in the diagnosis and putatively follow up of lymphomas

Article Info

Article Type

Case Report

Publication history

Received: Sat 09, Mar 2019
Accepted: Mon 25, Mar 2019
Published: Fri 12, Apr 2019

Copyright

© 2023 Federico Rossari. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2019.02.02