Metabolic complete response after docetaxel, cisplatin and S-1 (DCS) therapy and sequential radiation therapy in a patient with anal squamous cell carcinoma: a case report

Metabolic complete response after docetaxel, cisplatin and S-1 (DCS) therapy and sequential radiation therapy in a patient with anal squamous cell carcinoma: a case report

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Corresponding Author
Yasushi Tsuji
Department of Medical Oncology, Tonan Hospital, Sapporo, Japan

A B S T R A C T

Chemoradiotherapy is the standard treatment for anal squamous cell carcinoma (SCC). Recently,it has been reported that a combination therapy of taxane, platinum and fluoride pyrimidine is useful for SCC. A 58-year-old woman was admitted to our hospital with anal pain and constipation. Computed tomography (CT) scan revealed a 9×6 cm tumor, stenosis in the anal region, and swollen pelvic and inguinal lymph nodes. She underwent laparoscopic ileal stomatoplasty and biopsy. A diagnosis of SCC of anal canal was confirmed by histopathological examination. She received a combination therapy with docetaxel, cisplatin and S-1 (DCS), followed by radiation therapy (RT). After her chemoradiotherapy, no abnormal accumulation was observed on a positron emission tomography-computed tomography (PET-CT) scan, and she was diagnosed with metabolic complete response (CR). The 3-drug combination therapy of taxane, platinum, fluoride pyrimidine followed by RT as primary treatment may be effective in the treatment of anal SCC.

Article Info

Article Type
Case Report
Publication history
Received: Wed 18, Apr 2018
Accepted: Mon 30, Apr 2018
Published: Sun 06, May 2018
Copyright
© 2023 Yasushi Tsuji. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2018.10.011