Cytogenetic analysis of foundry molders using the micronucleus frequency in exfoliated buccal mucosa

Author Info

Saranya R Singaravelu

Corresponding Author

Saranya R Singaravelu
Assistant Professor, PG & Research Department of Biotechnology, Hindusthan College of Arts and Science, Nava India, Coimbatore, India

A B S T R A C T

Foundry workers are exposed to chemical substances such as, PAHs, toluene, phenol, sulphur oxides, etc which can be inhaled, absorbed or possibly ingested. Micronuclei in exfoliated buccal epithelial cells are widely used as biomarkers of cancer risk in humans. We analyzed the frequency of Micronucleated cells (MNC) of 100 foundry workers involved in moulding or melting processes and equal number of age and sex matched healthy volunteers enrolled as controls. Assessment was carried out on the incidence of MNC, binucleated cells (BNC), broken egg cells (BEC), budding cells (BC), and the other anomalies (OA), in 2000 cells per individual. The data were analyzed with SPSS, using the Mann-Whitney U-test, α = 0.05. The mean number of anomalies in foundry workers was 2.03 ± 0.13 MNC; 8.55 ± 0.26 BNC; 9.04 ± 0.13 BEC; 0.36 ± 0.09 BC, and 19.92 ± 0.03 OA; in controls it was 0.32 ± 0.03 MNC; 5.17 ± 0.03 BNC; 5.87 ± 0.09 BEC; 0.11 ± 0.13 BC, and 11.56 ± 0.08 OA; the differences for all parameters were significant. The non-occupational factors did not significantly influence the alterations.

Article Info

Article Type

Research Article

Publication history

Received: Mon 12, Mar 2018
Accepted: Tue 20, Mar 2018
Published: Mon 02, Apr 2018

Copyright

© 2023 Saranya R Singaravelu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2018.10.005