Evaluation of Anticancer Activities of Clerodendrum formicarum Gurke (Lamiaceae) and Syzygium Cordatum Hochst ex Krauss (Myrtaceae) Harvested in the City of Lubumbashi and its Surroundings in the Democratic Republic Of The Congo

Evaluation of Anticancer Activities of Clerodendrum formicarum Gurke (Lamiaceae) and Syzygium Cordatum Hochst ex Krauss (Myrtaceae) Harvested in the City of Lubumbashi and its Surroundings in the Democratic Republic Of The Congo

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Corresponding Author
Topwe Milongwe Mwene-Mbeja
Department of Chemistry, Faculty of Science, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo (DRC)

A B S T R A C T

The main objective of this study was to extract the essential oils from Clerodendrum formicarum and Syzygium cordatum in order to determine the anticancer activity and establish the chemical constituents of that kind of essential oils. Hence, we have used hydrodistillation method to obtain the desired extracts or samples of essential oils. Indeed, the assessment of the anticancer activities showed that, at 100 µg/mL, the essential oils from S. cordatum inhibited the proliferation (98.2%) of breast cancer (MCF-7) cells. In the same context, the essential oils from C. formicarum also inhibited the proliferation (98.9%) of breast cancer (MCF-7) cells. We have additionally determined the chemical composition of the essential oils by GC-MS and identified 17 compounds in C. formicarum including caryophyllene (18.6%), (E)-3,7-dimethylocta1,3,6-triene (7.6%), β-Myrcene (6.2%), and [1S-(1α, 7α, 8α)]-1,8a-dimethyl-7-(1-methylethenyl)- 1,2,3,5,6,7,8,8a-octahydronaphthalene (5.6%) as major compounds. We have observed an unknown compound (25%) in the essential oils from C. formicarum (H-12) The chemical analysis showed 28 compounds in S. cordatum (HE-9) essential oils such as caryophyllene (7.2%) and cedrene (6.7%) as major compounds

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Article Type
Research Article
Publication history
Received: Mon 06, Apr 2020
Accepted: Tue 21, Apr 2020
Published: Mon 29, Jun 2020
Copyright
© 2021 Topwe Milongwe Mwene-Mbeja. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.
DOI: 10.31487/j.CMR.2020.01.04